Mechanobiology, Injury and Health
Determination of mRNA TNFα levels in peripheral blood leukocytes from SMT-treated asymptomatic subjects
Previous work from our laboratory has suggested that normal subjects who received a single manipulative therapy demonstrate a significantly reduced production of the soluble inflammatory mediators, tumor necrosis factor β, (TNFα) and interleukin-1 β, (IL-1β) (Teodorczk-Injeyan et al, 2005). These results are in concordance with other reports on the anti-inflammatory potential of SMT (Song et al, 2005; Mohammadian et al 2002). In vivo studies have shown alleviation of symptoms and shortening of the duration of pain and hyperalgesia caused by experimental induction of intervertebral foramen (IVF) inflammation following application of a manipulative force in an animal model (Song et al, 2005). Furthermore, using the same model, a manipulative force applied by activator was able to reduce hyperexcitibility in inflamed dorsal ganglion neurons thus, possibly, leading to a decrease in pain (Song et al, 2005). In contrast, Xu et al. have recently shown that neuropathic pain is associated with the up-regulation of immunoactive TNFα production (Xu et al, 2006).
While the available evidence suggests that spinal manipulative therapy can produce anti-inflammatory systemic effects, potential mechanisms underpinning such effects have not been explored. The proposed study will begin such an investigation.